Head Coach: Eddie George (1st season)
Stadium: Nissan Stadium, Nashville, TN
Record: 5-6
Previous: 2020
Next: 2022
Schedule/Results[]
| Date | Opponent | Result | Score | Record |
|---|---|---|---|---|
| 9/5 (Sun) | Grambling (1) | L | 10-16 | 0-1 |
| 9/11 | Jackson State (2) | L | 16-38 | 0-2 |
| 9/18 | Kentucky State | W | 41-7 | 1-2 |
| 9/25 | @ Southeast Missouri | L | 14-47 | 1-3 |
| 10/2 | @ Austin Peay | W | 24-22 | 2-3 |
| 10/16 | Tennessee Tech | W | 20-13 (OT) | 3-3 |
| 10/23 | @ Eastern Illinois | W | 28-0 | 4-3 |
| 10/30 | Murray State | W | 27-21 | 5-3 |
| 11/6 | @ Tennessee-Martin | L | 20-41 | 5-4 |
| 11/13 | Austin Peay | L | 7-36 | 5-5 |
| 11/20 | @ Mississippi State | L | 10-55 | 5-6 |
- (1) - @ Tom Benson Hall of Fame Stadium, Canton, OH
- (2) - @ Liberty Bowl Memorial Stadium, Memphis, TN