Head Coach: Bill Cronin (25th season)
Stadium: Toyota Stadium, Georgetown, KY
Record:
Previous: 2020
Next: 2022
Schedule/Results
| Date | Opponent | Result | Score | Record |
|---|---|---|---|---|
| 9/4 | Ave Maria | W | 42-10 | 1-0 |
| 9/11 | @ Webber International | W | 31-21 | 2-0 |
| 9/25 | @ Bluefield | W | 61-19 | 3-0 |
| 10/2 | Pikeville | W | 52-14 | 4-0 |
| 10/9 | @ Bethel (TN) | L | 24-25 | 4-1 |
| 10/16 | @ Lindsey Wilson | L | 0-35 | 4-2 |
| 10/23 | Thomas More | W | 27-17 | 5-2 |
| 10/30 | @ Campbellsville | W | 42-3 | 6-2 |
| 11/6 | Cumberlands (KY) | W | 28-7 | 7-2 |
| 11/13 | Cumberland (TN) | W | 28-10 | 8-2 |