Head Coach: Mark Dantonio (5th season)
Stadium: Spartan Stadium, East Lansing, MI
Record: 11-3 (7-1 Big Ten Conference)
Previous: 2010
Next: 2012
Schedule/Results[]
| Date | Opponent | Result | Score | Record |
| 9/2 (Fri) | Youngstown State | W | 28-6 | 1-0 |
| 9/10 | Florida Atlantic | W | 44-0 | 2-0 |
| 9/17 | @ Notre Dame | L | 13-31 | 2-1 |
| 9/24 | Central Michigan | W | 45-7 | 3-1 |
| 10/1 | @ Ohio State | W | 10-7 | 4-1 (1-0) |
| 10/15 | Michigan | W | 28-14 | 5-1 (2-0) |
| 10/22 | Wisconsin | W | 37-31 | 6-1 (3-0) |
| 10/29 | @ Nebraska | L | 3-24 | 6-2 (3-1) |
| 11/5 | Minnesota | W | 31-24 | 7-2 (4-1) |
| 11/12 | @ Iowa | W | 37-21 | 8-2 (5-1) |
| 11/19 | Indiana | W | 55-3 | 9-2 (6-1) |
| 11/26 | @ Northwestern | W | 31-17 | 10-2 (7-1) |
| 2011 Big Ten Championship (@ Lucas Oil Stadium, Indianapolis, IN) | ||||
| 12/3 | Wisconsin | L | 39-42 | 10-3 (7-1) |
| Outback Bowl (@ Raymond James Stadium, Tampa, FL) | ||||
| 1/2 | Georgia | W | 33-30 (3OT) | 11-3 (7-1) |