2010 Duke Blue Devils
Head Coach: David Cutcliffe (3rd season)
Stadium: Wallace Wade Stadium, Durham, NC
Record: 3-9 (1-7 ACC)
Previous: 2009
Next: 2011
Schedule/Results[]
| Date | Opponent | Result | Score | Record |
| 9/4 | Elon | W | 41-27 | 1-0 |
| 9/11 | at Wake Forest | L | 48-54 | 1-1 (0-1) |
| 9/18 | Alabama | L | 13-62 | 1-2 (0-1) |
| 9/25 | Army | L | 21-35 | 1-3 (0-1) |
| 10/2 | at Maryland | L | 16-21 | 1-4 (0-2) |
| 10/16 | Miami (FL) | L | 13-28 | 1-5 (0-3) |
| 10/23 | at Virginia Tech | L | 7-44 | 1-6 (0-4) |
| 10/30 | at Navy | W | 34-31 | 2-6 (0-4) |
| 11/6 | Virginia | W | 55-48 | 3-6 (1-4) |
| 11/13 | Boston College | L | 16-21 | 3-7 (1-5) |
| 11/20 | at Georgia Tech | L | 20-30 | 3-8 (1-6) |
| 11/27 | North Carolina | L | 19-24 | 3-9 (1-7) |