2012 San Francisco 49ers

The  San Francisco 49ers season will be the franchise's upcoming 63rd season in the National Football League, the 67th overall and the second under the head coach/general manager tandem of Jim Harbaugh and Trent Baalke.

2012 draft board

 * Note: Exact numbers of the selections from rounds 4–7 will be determined later in the spring after compensatory selections are awarded.

Schedule
The 49ers' preseason opponents and schedule will be announced in the spring.

2012 opponents
Listed below are the 49ers' opponents for 2012. Exact dates and times will be announced in the spring.