2019 Indianapolis Colts season

The 2019 Indianapolis Colts season is the franchise's 67th season in the National Football League and their 36th in Indianapolis. It is also their second season under head coach Frank Reich and third under the leadership of general manager Chris Ballard.

For the first time since 2011, quarterback Andrew Luck will not be on the roster, as he announced his retirement on August 24, 2019. A four-time Pro Bowler and the top pick in the 2012 Draft, Luck led the Colts to four playoff appearances (2012-2014, 2018), an appearance in the AFC Championship Game in the 2014 season (the franchise’s only time doing so in the post-Peyton Manning era), and won the NFL Comeback Player of the Year award in 2018. A four-year cycle of injuries and rehab that dated back to 2015 has "taken his joy of this game away," which led to his decision of retiring.

The Colts will attempt to improve on their 10–6 campaign from 2018 that saw them make the playoffs for the first time since 2014.

Draft
Notes
 * As the result of a negative differential of free agent signings and departures that the Colts experienced during the free agency period, the team was awarded one compensatory selection for the 2019 draft.
 * The Colts acquired the Raiders' fourth-round pick (109th) in exchange for their two fourth-round picks (129th and 135th)

Preseason
The team was rocked by the decision August 24 by starting quarterback Andrew Luck that he would immediately retire from professional football due to chronic injury problems and the emotional and mental strain they had extracted. Luck, the 2018 NFL Comeback Player of the Year, had been battling a mysterious and slow-healing leg injury, described by the team variously as a "calf strain" and a "high ankle issue."

Luck, a 7-year professional with four appearances in the NFL Pro Bowl, indicated that he had been contemplating leaving the game for a week-and-a-half or two weeks prior to his announcement; he had been speaking with team officials about the matter all week. In a news conference Luck indicated that his recurring injuries had "taken my joy of this game away.... After 2016, I played in pain and was unable to practice, I said I wouldn't go through that again."

The team moved forward with former New England Patriots backup Jacoby Brissett, a third-year Colt, as its designated starting quarterback.

Schedule
Notes
 * Intra-division opponents are in bold text.
 * Networks and times for Sunday games from Weeks 5–17 are subject to change as a result of flexible scheduling.

Week 2: at Tennessee Titans
